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Presence of two or more of the following accompanying symptoms. sweating, difficulty swallowing, tremor, difficulty urinating, changes in consciousness from delirious to comatose, mutism, tachycardia, increased or unstable blood pressure, leukocytosis, increased activity of abilify pills. WITH . Symptoms of groups A and B should not be caused by the development of any neurological disease (viral encephalitis, vascular or space-occupying lesions of the central nervous system), or by taking other drugs that can produce symptoms similar to NMS (phencyclidine, amphetamines, monoamine oxidase inhibitors, dopaminergic blockers and etc.). D. Symptoms of groups A and B should not be a consequence of psychopathological conditions occurring with catatonic symptoms (catatonic form of schizophrenia, affective disorders with catatonic symptoms).

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Doug Clouse MD
Neuroleptic malignant syndrome (NMS) is an acute life-threatening condition that is most often a complication of neuroleptic therapy.
It can also occur while taking other drugs that block dopamine receptors. Despite the achievements of modern medicine, the mortality rate from neuroleptic malignant syndrome is still 5–20%. Even timely placement of the patient in a specialized intensive care unit does not always guarantee a favorable outcome of this condition if the existing disorders increase and are not corrected.
Danton Dungy MD
The subtle biochemical mechanisms of the brain and the whole body continue to buy abilify online.
According to modern views, neuroleptic malignant syndrome is predominantly of central origin. This means that the main disorders occur in the brain, or rather, in its subcortical structures. But the effect of drugs on skeletal muscles is of some importance. This leads to the destruction of muscle cells (rhabdomyolysis) and binding of peripheral dopamine receptors.
Adam Farber MD
Under the influence of neuroleptics and some other drugs, a massive blockade of central dopamine receptors occurs in the hypothalamus and basal ganglia.
This causes metabolic disorders, persistent hyperthermia (increased body temperature) and severe motor disorders of the extrapyramidal type, the most important of which is muscle rigidity. Disruption of dopamine metabolism changes the activity of the serotonergic system in the brain, and subsequently cascade reactions develop with disruption of the functioning of other neurotransmitters. As a result, the sympathetic nervous system is disinhibited, autonomic disorders appear and increase, and heart function is disrupted.
Steven Hatfield DO
Central disruption of water and mineral metabolism leads to buy aripiprazole online in the permeability of the blood-brain barrier.
In an unfavorable course, neuroleptic malignant syndrome is often complicated by cerebral edema, pulmonary edema, cardiovascular failure, and acute impairment of the kidneys and liver. These are all possible causes of aripiprazole pills. Neuroleptic malignant syndrome is an iatrogenic psychoneurosomatic condition, that is, it occurs only in response to therapy and is directly related to a specific medication.
John Jones MD
The main drugs that can cause NMS.
Because of this, various substances toxic to them begin to flow through the walls of the vessels to the nerve cells, swelling and subsequent swelling of the brain occurs. All this leads to mental disorders and various disturbances in the level of consciousness. In the blood plasma, a shift in the acid-base balance and a change in the concentration of basic electrolytes occurs.
Benjamin MacQueen MD
Neuroleptic malignant syndrome includes a complex of characteristic disorders.
NMS occurs quite rarely when taking antidepressants; disturbances in dopamine metabolism are secondary to changes in the functioning of the serotonergic system. The effect of lithium preparations is due to a neurotoxic effect, which can occur when the therapeutic concentration is exceeded, long-term uncontrolled use and against the background of impaired renal function.
George K Myo MD
Existing organic cerebral insufficiency, dehydration, physical exhaustion, fasting, the postpartum period, and anemia predispose to the development of NMS. Even mild history of brain damage may affect the tolerability of antipsychotic therapy. Therefore, people with perinatal damage to the nervous system, those who have suffered traumatic brain injuries and neuroinfections, and those suffering from alcoholism, degenerative and demyelinating diseases of the head are at risk for the development of complications.no brain.
Steven Porter MD
Rigidity is an increase in muscle tone, which leads to their compaction and limitation of active and passive movements.
Some of them are mandatory and are included in the diagnostic criteria, others do not always occur and are therefore considered optional (additional). Obligatory symptoms include muscle rigidity, fever, autonomic disorders and mental disorders.
Gregory Stewart MD
All this is complemented by signs of dehydration.
At the same time, the tone in the flexors increases more than in their antagonists. Therefore, a person experiences a forced position of the body and limbs. Sometimes the rigidity is so severe that it is almost impossible for a patient with NMS to bend an arm or leg. This is called the lead pipe symptom. Rigidity is usually the first sign of neurolepsy; it increases rapidly and is combined with severe and persistent hyperthermia.

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An increase in muscle tone occurs according to the extrapyramidal type, therefore the symptom of a gear wheel is detected (stepped movements when flexion occurs in small jerks with pauses between them). Other extrapyramidal signs are often detected. This may be tremor (shaking), akathisia (restlessness), dystonia, oculogyric crises (rolling the eyeballs upward), foot clonus, increased tendon reflexes, myoclonus. Swallowing and pronunciation of sounds are also impaired, and a mask-like appearance of the face appears.

  • Neuroleptic malignant syndrome can occur with abrupt withdrawal of correctors and antiparkinsonian drugs, so it is sometimes observed after an abrupt irrational change in therapy in patients with Parkinson's disease or syndrome.
  • Autonomic disorders manifest themselves in instability of blood pressure, heart rhythm disturbances, tachycardia (increased heart rate), sweating, salivation, characteristic greasiness of the skin with a simultaneous decrease in its elasticity, and urination disorders.
  • Mental disorders increase as disorders of water-electrolyte and neurotransmitter metabolism progress.
  • Anxiety, psychomotor agitation, confusion, delirium, oneiroid, amentia, catatonia, stupor and coma may occur.
  • It is important to timely assess changes in the patient’s condition and not miss the transformation of psychosis as a result of increasing changes in the brain. This will allow you to identify neuroleptic malignant syndrome in the early stages and stop the medications you are receiving.

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